The host Lancers trailed by just three points at halftime, but couldn't quite get over the hump in first-year coach Jason Coker's debut.
Elizabeth Alia led St. Joseph with nine points, followed by Katie Matrise and Alexis Mattox with seven apiece.
"Even though we fell short, we showed a lot of energy and improvement during the course of the game on both sides of the ball," Coker said.
"That's all I can ask for from our ladies in a season opener under a new system. There were a lot of positives to take away, which gives us some momentum in our preparation for Friday night."